Megachrome - Revision history

Semaiophoron: fix discovery date

2024-09-17T04:58:24Z

fix discovery date

← Older revision		Revision as of 04:58, 17 September 2024
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	'''Megachrome''' (often simply called '''mega''', sometimes euphemistically referred to as '''MCUltra''' or simply '''ultra''') is a hypersynthetic stimulant and nootropic discovered in ~~2993~~ that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally.		'''Megachrome''' (often simply called '''mega''', sometimes euphemistically referred to as '''MCUltra''' or simply '''ultra''') is a hypersynthetic stimulant and nootropic discovered in 2758 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally.

	== Pharmacokinetics ==		== Pharmacokinetics ==

Semaiophoron at 04:53, 17 September 2024

2024-09-17T04:53:00Z

← Older revision		Revision as of 04:53, 17 September 2024
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	== Legality ==		== Legality ==
	Megachrome is legal worldwide, with many governments even subsidizing its use due to its effects on economic output ~~and~~ longevity increasing effects.		Megachrome is legal worldwide, with many governments even subsidizing its use due to its effects on economic output alongside its longevity increasing effects.

Semaiophoron: add legality

2024-09-17T04:52:31Z

add legality

← Older revision		Revision as of 04:52, 17 September 2024
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	Concerns have been raised over what has been dubbed "Megapsychosis" in heavy users, with some detractors arguing that the increasingly incomprehensible thoughts after heavy use for several weeks should be considered indicative of neurological damage. But defenders argue that brain scans show a different story, with heavy increases in gray matter, white matter and the corpus callosum, and suggest that detractors are simply not sufficiently advanced to understand the concepts being discussed by heavy users.		Concerns have been raised over what has been dubbed "Megapsychosis" in heavy users, with some detractors arguing that the increasingly incomprehensible thoughts after heavy use for several weeks should be considered indicative of neurological damage. But defenders argue that brain scans show a different story, with heavy increases in gray matter, white matter and the corpus callosum, and suggest that detractors are simply not sufficiently advanced to understand the concepts being discussed by heavy users.

			== Legality ==
			Megachrome is legal worldwide, with many governments even subsidizing its use due to its effects on economic output and longevity increasing effects.

Semaiophoron: add slang

2024-09-17T04:48:03Z

add slang

← Older revision		Revision as of 04:48, 17 September 2024
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	'''Megachrome''' is a hypersynthetic stimulant and nootropic discovered in 2993 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally.		'''Megachrome''' (often simply called '''mega''', sometimes euphemistically referred to as '''MCUltra''' or simply '''ultra''') is a hypersynthetic stimulant and nootropic discovered in 2993 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally.

	== Pharmacokinetics ==		== Pharmacokinetics ==

Semaiophoron: Created page with "'''Megachrome''' is a hypersynthetic stimulant and nootropic discovered in 2993 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally. == Pharmacokinetics == Megachrome exhibits linear time-independent kinetics following single and multiple oral dose administration, with the liver and kidneys both contributing to its breakdown. In addition to its own stimulant effects, it acts as a p..."

2024-09-17T03:47:12Z

Created page with "'''Megachrome''' is a hypersynthetic stimulant and nootropic discovered in 2993 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally. == Pharmacokinetics == Megachrome exhibits linear time-independent kinetics following single and multiple oral dose administration, with the liver and kidneys both contributing to its breakdown. In addition to its own stimulant effects, it acts as a p..."

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'''Megachrome''' is a hypersynthetic stimulant and nootropic discovered in 2993 that is 4,000 times more potent than amphetamine without any cardiovascular side effects and a half life of 43 hours when administered orally.

== Pharmacokinetics ==
Megachrome exhibits linear time-independent kinetics following single and multiple oral dose administration, with the liver and kidneys both contributing to its breakdown. In addition to its own stimulant effects, it acts as a prodrug of a plethora of other known and unknown stimulants.

== Pharmacodynamics ==
Megachrome has hyperagonist activity at TAAR1, σ1, 5HT2a, most nAChRs, and many other receptors, while acting as a extremely effective Monoamine Reuptake ''Enhancer'', with total antagonist activity at D2R, and completely inhibiting MAO and COMT. It acts as a very strong allosteric modulator for many other receptors, thought to be the cause for the lack of cardiovascular side effects. In addition, it has been noted that the user does not seem to build tolerance to the drug, possibly due to D2R antagonism or unknown secondary mechanisms. Surprisingly, in many cases sensitization to the nootropic and stimulant effects have instead been reported.

Incredible increases in BDNF have been observed in frequent users, but it is unclear if this is through direct pharmacological means, lack of sleep, behavioral changes, or a combination of the three.

Megachrome increases production of NOS, but it also enhances production of PDE5 in equal measure, leading to no noticeable effects. However, many users have suggested that it exhibits highly synergistic effects when combined with extremely high doses of PDE5 inhibitors

== Toxicity ==
The LD50 for oral consumption in humans has not been determined, but it has been demonstrated that even the most extreme use imaginable does not result in death. Many studies have shown that due to its cardio-optimizing and cardio-stabilizing mechanisms it actually seems to increase longevity in its users.

Concerns have been raised over what has been dubbed "Megapsychosis" in heavy users, with some detractors arguing that the increasingly incomprehensible thoughts after heavy use for several weeks should be considered indicative of neurological damage. But defenders argue that brain scans show a different story, with heavy increases in gray matter, white matter and the corpus callosum, and suggest that detractors are simply not sufficiently advanced to understand the concepts being discussed by heavy users.